Arsenal will face holders Barcelona in the Champions League final 16.
Chelsea have been drawn against Paris St-Germain for the third consecutive season, whilst Manchester City face Dynamo Kiev.
Roma versus Real Madrid and Juventus, last year’s beaten finalists, against Bayern Munich are two of the standout matches in the draw.
1st legs are scheduled to take spot on 16-17 and 23-24 February. Return legs are on 8-9 and 15-16 March.
The winners of each group, which includes Chelsea and Manchester City, are at home in the second legs, even though Arsenal will host their very first leg.
Barcelona v Arsenal is a repeat of the 2006 final, which the Spanish champions won 2-1 thanks to two late targets in Paris.
PSG, who are 17 points clear at the leading of the French league, knocked Chelsea out on away goals at this stage last season, whilst the Blues beat them on the exact same rule in the quarter-finals the earlier year.
Dynamo Kiev beat Manchester City in the 2010-11 Europa League final 16, with striker Mario Balotelli sent off for the English side.
The first leg in Kiev will be played in an empty stadium, as Dynamo Kiev had been punished following racist attacks on fans in the course of a group game against Chelsea.
The draw for the quarter-finals will be held on 18 March with the semi-final line-up drawn on 15 April.
Draw in full
Gent v Wolfsburg
Roma v Actual Madrid
Paris St-Germain v Chelsea
Arsenal v Barcelona
Juventus v Bayern Munich
PSV Eindhoven v Atletico Madrid
Benfica v Zenit St Petersburg
Dynamo Kiev v Manchester City